But the nerve cells in the brain are packed very densely. There is therefore a danger that the molecules not only reach the neuron for which they are intended, but also stimulate other neurons in the neighborhood. This is where the "closed doors" come into play: Specialized cells in the brain, the astrocytes, rapidly reabsorb the glutamate. This way they shield communication to a certain extent. "They do this by sending extensions near synapses, the so-called perisynaptic astrocyte processes or PAPs," explains Prof. Dr. Christian Henneberger from the Institute of Cellular Neurosciences at the University of Bonn.

Molecular glutamate vacuum cleaners

PAPs have specialized transporters that remove the glutamate around the synapses, like small vacuum cleaners. The effectiveness of this mechanism is apparently strictly regulated: The researchers triggered a kind of cellular learning through a repeated electrical stimulation. This causes the receiver cell to respond more strongly to the signals of the transmitting cell in the long term. Experts also speak of "long-term potentiation" (LTP).

"We have now been able to demonstrate that PAPs retreat during this learning process," explains Prof. Dr. Dmitri Rusakov from the Institute of Neurology at University College London. "This increases the likelihood that neighboring cells are also stimulated by the glutamate release." This means that signal transmission also becomes less exclusive, which could explain other interesting observations where the cause was previously unclear: For example, LTP can also affect close connections between other nerve cells.
"This may be important for later learning processes," Henneberger suspects.

Large synapses are less discreet

Some synapses also seem to be inherently less discreet than others. Together with his colleague Dr. Michel Herde and other researchers, Henneberger was able to show this in a study published a few days ago in "Cell Reports". The transmitter cell often releases its glutamate into the synaptic cleft at certain structures, the so-called spines. These are tiny extensions of the downstream receiving nerve cell. The PAPs often cover these spines almost like a glove. However, the larger a spine is, the patchier is this coating and the more glutamate can escape. "In the vicinity of large and strong synapses, other nerve cells are therefore probably excited more frequently,"
says Herde. In other words: Nerve cells with strong synaptic connections rarely speak behind closed doors.