Tuberculosis: Discovery of an ancestral lineage in the African Great Lakes region

Eurekalert 10 Giu 2020
Scienceonline
0 commento

 

Two exceptional strains of tuberculosis, isolated from East African patients with multi-resistant forms of the disease, have been discovered thanks to the use of a new molecular test, Deeplex-MycTB[1]. These strains belong to a so far unknown bacterial lineage, apparently limited to the African Great Lakes region. Genome analyses show that this lineage originated from an ancestral phylum which predates the branching point shared by all other lineages of common tuberculosis strains known to date.

This discovery reinforces the hypothesis of an East African origin for the tuberculosis bacillus, which remains the main cause of death from infectious causes, and provides additional molecular clues about the evolution towards a pathogenic lifestyle. This work, carried out by an international team led by researchers from the Lille Centre for Infection and Immunity (CNRS/Inserm/Institut Pasteur de Lille/Université de Lille/CHU de Lille), is published on June 9th 2020 in Nature Communications.

 

Note

[1] Deeplex-MycTB is an antibiotic resistance prediction test for Mycobacterium tuberculosis developed by GenoScreen in collaboration with Dr Philip Supply.

Vota questo articolo
(0 Voti)
Altro in questa categoria: « Corona pandemic poses new challenges Self-healing bone cement »

Lascia un commento

Assicurati di aver digitato tutte le informazioni richieste, evidenziate da un asterisco (*). Non è consentito codice HTML.

Torna in alto

 

Scienzaonline con sottotitolo Sciencenew  - Periodico
Autorizzazioni del Tribunale di Roma – diffusioni:
telematica quotidiana 229/2006 del 08/06/2006
mensile per mezzo stampa 293/2003 del 07/07/2003
Scienceonline, Autorizzazione del Tribunale di Roma 228/2006 del 29/05/06
Pubblicato a Roma – Via A. De Viti de Marco, 50 – Direttore Responsabile Guido Donati

Photo Gallery