Scienceonline - Last News

Single brain scan can diagnose Alzheimer’s disease

Single brain scan can diagnose Alzheimer’s disease

23 Giugno 2022

A single MRI scan of the brain could be enough...

Researchers create ‘time machine’ simulations studying the lifecycle of ancestor galaxy cities

Researchers create ‘time machine’ simulations studying the lifecycle of ancestor galaxy cities

06 Giugno 2022

For the first time, researchers have created simulations that directly...

Unlocking the secrets of killer whale diets and their role in climate change

Unlocking the secrets of killer whale diets and their role in climate change

20 Maggio 2022

Killer whale populations are invading the Arctic, causing significant disruptions...

New mechanism for regulating supply of DNA building blocks may lead to better antibiotics

New mechanism for regulating supply of DNA building blocks may lead to better antibiotics

19 Maggio 2022

In a new study published in Nature Communications, researchers from...

New study reveals impact of sea level rise on human groups during Mesolithic and Neolithic periods

New study reveals impact of sea level rise on human groups during Mesolithic and Neolithic periods

19 Maggio 2022

A study carried out in the area around the Pego-Oliva...

Snake-like limb loss in a Carboniferous amniote

11 Aprile 2022

Among living tetrapods, many lineages have converged on a snake-like...

Protein boosts height growth in girls

Protein boosts height growth in girls

07 Aprile 2022

Protein boosts height growth in girls. Just seven grams over...

Fungicide combo against devastating red clover disease

Fungicide combo against devastating red clover disease

07 Marzo 2022

Red clover, an important forage crop for grazing cattle, can...

A new role for an old immune cell may lead to novel therapies for infection and cancer

University of Birmingham 02 Mar 2017
2095 volte

A new study has identified a previously undescribed role for a type of unconventional T cell with the potential to be used in the development of new therapies for infection and cancer. The study, published today in Nature Communications, shows that Gamma Delta T cells are able to generate immunological memory against previous infections and cancerous targets. The results challenge the textbook description of Gamma Delta T cells as ‘natural born killers’ with an innate ability to recognise and destroy abnormal cells.

Lead author of the study, Professor Ben Willcox from the Institute of Immunology and Immunotherapy at the University of Birmingham, explains the key findings: “Instead of being ‘natural born killers’, we found these cells are actually quite smart. They adapt to and remember what they have encountered in life, which may include infections and pre-cancerous cells. “This phenomenon of ‘immunological memory’ is what current vaccines exploit, but because Gamma Delta T cells recognise their targets in a different way, they present novel routes to generate vaccines, and also cell therapy approaches against infection and cancer.”

 

In order to harness these “adaptive” abilities of Gamma Delta T cells, work is now required to identify the mechanism by which they recognise abnormal cells. “We are working with other partners to understand exactly how these cells recognise signs of abnormality in infection and cancer, focussing on human cohorts. This knowledge will be crucial to help us build on the current study and explore how to develop new cell therapies and vaccines that exploit Gamma Delta T cells,” adds Professor Willcox.

Vota questo articolo
(0 Voti)

Lascia un commento

Assicurati di aver digitato tutte le informazioni richieste, evidenziate da un asterisco (*). Non è consentito codice HTML.

 

Scienzaonline con sottotitolo Sciencenew  - Periodico
Autorizzazioni del Tribunale di Roma – diffusioni:
telematica quotidiana 229/2006 del 08/06/2006
mensile per mezzo stampa 293/2003 del 07/07/2003
Scienceonline, Autorizzazione del Tribunale di Roma 228/2006 del 29/05/06
Pubblicato a Roma – Via A. De Viti de Marco, 50 – Direttore Responsabile Guido Donati

Photo Gallery